Research progress of pulmonary microenvironment-mediated changes in cell metabolism in acute lung injury

doi:10.3877/cma.j.issn.2096-1537.2022.01.012

Abstract

Abstract:

Acute lung injury (ALI) is one of the most common clinical lung lesions. Its pathological manifestations are severe pulmonary edema and hyaline membrane formation, which cause changes in the pulmonary microenvironment. Metabolomics monitored the changes in endogenous metabolites (such as sugars, lipids, and amino acids) to reflect the physiological or pathological state of an organism. In view of the active metabolism of human lungs, a large amount of studies in recent years have shown that the changes in cell metabolism mediated by pulmonary microenvironment are of great significance for the occurrence of ALI, and provide a new means for the early warning, diagnosis and treatment of ALI patients. In this paper, the application and research progress of cellular metabolic changes in ALI are briefly reviewed.

Key words: Acute lung injury, Cell metabolism, Pulmonary microenvironment

Mengting Chen, Xiaoxiao Meng, Ruilan Wang. Research progress of pulmonary microenvironment-mediated changes in cell metabolism in acute lung injury[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2022, 08(01): 80-84.

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URL: https://icu.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2096-1537.2022.01.012

https://icu.cma-cmc.com.cn/EN/Y2022/V08/I01/80

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