Research progress of sepsis and iron metabolism

doi:10.3877/cma.j.issn.2096-1537.2022.01.011

Abstract

Abstract:

Sepsis is a common systemic inflammatory response syndrome caused by infection, characterized by high incidence rate and high mortality. It has become one of the important public health problems. Therefore constant researches have been conducting focused on it and its pathogenesis and treatment. In 2016, sepsis was redefined as a life-threatening organ dysfunction pattern caused by the host's dysresponse to infection. In recent years, a great amount of clinical and experimental studies have been conducted on the immune response and metabolic changes of patients with sepsis, among which the relationship between iron and metabolism and sepsis is also one of the key points. Iron plays a key role in regulating immune function and microbial growth, and it has been shown that changes in iron metabolism can affect the risk of infection. In order to provide new directions for the prognosis prediction and treatment of sepsis, this paper aims to give a brief overview of the relationship between metabolism and sepsis and sepsis-induced multiple organ dysfunction.

Key words: Sepsis, Iron metabolism, Multiple organ dysfunction

Xianghui Li, Jiangquan Yu, Jing Wang. Research progress of sepsis and iron metabolism[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2022, 08(01): 74-79.

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