Research advances of β1-adrenergic receptor desensitization in sepsis-induced myocardial dysfunction

doi:10.3877/cma.j.issn.2096-1537.2019.03.014

Abstract

Abstract:

Sepsis-induced myocardial dysfunction (SIMD) is an important cause of poor prognosis of sepsis. Abnormalities in the β-adrenergic receptor (β-AR) signaling pathway such as β-AR receptor desensitization may cause cardiac dysfunction. The mechanisms of β-AR receptor desensitization include receptor resolution, coupling, receptor endocytosis and down-regulation of gene expression, causing a decrease in the number and function of β-AR receptors. This article mainly discusses the relationship between β1-AR desensitization and SIMD, tries to provide a theoretical basis for the treatment of SIMD, and lays a foundation for further research.

Key words: Sepsis, Sepsis-induced myocardial dysfunction, β1 adrenergic receptor, Receptor desensitization

Haidan Zhang, Peiwu Li, Li Ma. Research advances of β1-adrenergic receptor desensitization in sepsis-induced myocardial dysfunction[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2019, 05(03): 278-281.

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https://icu.cma-cmc.com.cn/EN/Y2019/V05/I03/278

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