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Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition) ›› 2019, Vol. 05 ›› Issue (03): 282-285. doi: 10.3877/cma.j.issn.2096-1537.2019.03.015

Special Issue:

• Review • Previous Articles     Next Articles

The analysis of the influence of severe infection on the apparent volume of distribution of antibacterial drugs

Jie Yang1, Yingzi Huang1,()   

  1. 1. Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China
  • Received:2017-09-24 Online:2019-08-28 Published:2019-08-28
  • Contact: Yingzi Huang
  • About author:
    Corresponding author: Huang Yingzi, Email:

Abstract:

Sepsis is a major cause of mortality in intensive care unit (ICU). Early and correct antibacterial coverage is essential. But the pharmacokinetics (PK) of antibiotics can be compromised as a result of altered physiology in the critically ill patients. The apparent volume of distribution (Vd) is an important PK parameter and can determine the loading dose. This review article summarizes the key changes in Vd of antibiotic in patients with severe infection, and provides general suggestions on optimization of antibiotic dosing to deal with Vd challenges.

Key words: Sepsis, Antibacterial drugs, Apparent volume of distribution, Pharmacokinetic

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