Research progress of extracellular vesicles in vascular endothelial dysfunction in sepsis

doi:10.3877/cma.j.issn.2096-1537.2024.03.010

Abstract

Abstract:

Sepsis is life-threatening organ dysfunction resulting from a dysregulated host response to infection. Vascular endothelial injury is an important feature of sepsis, and inhibiting endothelial injury can help to improve organ function and prognosis in patients with sepsis. As an important carrier of intercellular communication, extracellular vesicles play an important role in vascular endothelial injury in sepsis by affecting the endothelial barrier, leukocyte adhesion, coagulation, angiogenesis and cell death. This paper summarizes the role of extracellular vesicles in vascular endothelial injury in sepsis, in order to further understand the pathogenesis of sepsis and provide new ideas for sepsis treatment.

Key words: Sepsis, Vascular endothelial dysfunction, Extracellular vesicles

Zihan Hu, Fei Peng, Qin Sun, Yi Yang. Research progress of extracellular vesicles in vascular endothelial dysfunction in sepsis[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2024, 10(03): 265-270.

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URL: https://icu.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2096-1537.2024.03.010

https://icu.cma-cmc.com.cn/EN/Y2024/V10/I03/265

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作用	囊泡来源	包含物质	作用
损伤作用	血浆	miR-210-3p	增强内皮通透性，扩大炎症反应，促进凋亡
	血浆	miR-1-3p	增强内皮通透性
	内皮细胞	酪氨酸激酶	增强内皮通透性
	单核细胞	IL-1β	增强内皮黏附作用
	单核细胞	线粒体成分	增强内皮黏附作用
	血浆	组织因子	促进血栓形成
	血小板	NLRP3	促进内皮焦亡
	巨噬细胞	miR-199a-5p	促进内皮焦亡
	单核细胞	GSDMD，N-GSDMD，caspase-1	促进内皮凋亡
	巨噬细胞	caspase-1	增强内皮通透性及黏附作用
保护作用	内皮细胞	miR-125b-5p	抑制内皮凋亡
	间充质干细胞	miR-377-3p	促进内皮损伤修复
	内皮祖细胞	miR-126	改善内皮通透性
	内皮细胞	miR-10a	改善内皮通透性
	间充质干细胞	Runx1p66	改善内皮通透性
	间充质干细胞	线粒体成分	改善内皮细胞线粒体功能和通透性
	干细胞	siICAM1	降低内皮黏附作用
	外周血	SOD2	抑制血栓形成
	脂肪来源的干细胞	未知	促进血管生成

作用	囊泡来源	包含物质	作用
损伤作用	血浆	miR-210-3p	增强内皮通透性，扩大炎症反应，促进凋亡
	血浆	miR-1-3p	增强内皮通透性
	内皮细胞	酪氨酸激酶	增强内皮通透性
	单核细胞	IL-1β	增强内皮黏附作用
	单核细胞	线粒体成分	增强内皮黏附作用
	血浆	组织因子	促进血栓形成
	血小板	NLRP3	促进内皮焦亡
	巨噬细胞	miR-199a-5p	促进内皮焦亡
	单核细胞	GSDMD，N-GSDMD，caspase-1	促进内皮凋亡
	巨噬细胞	caspase-1	增强内皮通透性及黏附作用
保护作用	内皮细胞	miR-125b-5p	抑制内皮凋亡
	间充质干细胞	miR-377-3p	促进内皮损伤修复
	内皮祖细胞	miR-126	改善内皮通透性
	内皮细胞	miR-10a	改善内皮通透性
	间充质干细胞	Runx1p66	改善内皮通透性
	间充质干细胞	线粒体成分	改善内皮细胞线粒体功能和通透性
	干细胞	siICAM1	降低内皮黏附作用
	外周血	SOD2	抑制血栓形成
	脂肪来源的干细胞	未知	促进血管生成

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