Research progress in sepsis immune disorder: thymic atrophy

doi:10.3877/cma.j.issn.2096-1537.2024.04.011

Abstract

Abstract:

One of the major causes of death in critically ill patients is sepsis, which results from a dysregulated immune response to infection.Both physiological and pathological development of thymus atrophy impairs body immune function.Multiple studies have shown that sepsis also leads to dramatically thymic atrophy, mainly manifested by increased apoptosis of thymocytes and damage of thymic epithelial cells, which is one of the important mechanisms of immune dysfunction in sepsis.More importantly, reversible recovery of thymus function may be closely related to prognosis of sepsis patients.An in-depth understanding of the mechanisms of acute thymic atrophy in sepsis and the development of related strategies to promote thymic recovery may provide new insights for sepsis immunotherapy.

Key words: Sepsis, Thymic atrophy, Immune dysfunction

Xi Chen, Zongsheng Wu, Mingzhu Zheng, Haibo Qiu. Research progress in sepsis immune disorder: thymic atrophy[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2024, 10(04): 379-383.

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URL: https://icu.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2096-1537.2024.04.011

https://icu.cma-cmc.com.cn/EN/Y2024/V10/I04/379

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References 43

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