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中华重症医学电子杂志 ›› 2019, Vol. 05 ›› Issue (01) : 64 -67. doi: 10.3877/cma.j.issn.2096-1537.2019.01.012

所属专题: 重症医学 文献

综述

Th17/Treg在急性呼吸窘迫综合征中免疫调节作用的研究进展
薛明1, 黄英姿1, 邱海波1, 余卫平2,()   
  1. 1. 210009 南京,东南大学附属中大医院重症医学科
    2. 210009 南京,东南大学医学院病理生理学系
  • 收稿日期:2018-05-02 出版日期:2019-02-28
  • 通信作者: 余卫平
  • 基金资助:
    国家自然科学基金项目(81571874); 江苏省自然科学基金项目(BK20141344); 江苏省医学重点学科(实验室)(ZDXKA2016025)

Advancements in the research on balance of T helper 17 and regulatory T cells in immunity of acute respiratory distress syndrome

Ming Xue1, Yingzi Huang1, Haibo Qiu1, Weiping Yu2()   

  1. 1. Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China
    2. College of Pathophysiology, School of medicine, Southeast University, Nanjing 210009, China
  • Received:2018-05-02 Published:2019-02-28
  • Corresponding author: Weiping Yu
引用本文:

薛明, 黄英姿, 邱海波, 余卫平. Th17/Treg在急性呼吸窘迫综合征中免疫调节作用的研究进展[J/OL]. 中华重症医学电子杂志, 2019, 05(01): 64-67.

Ming Xue, Yingzi Huang, Haibo Qiu, Weiping Yu. Advancements in the research on balance of T helper 17 and regulatory T cells in immunity of acute respiratory distress syndrome[J/OL]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2019, 05(01): 64-67.

急性呼吸窘迫综合征(ARDS)是临床常见危重病,病死率高达40%,炎症失衡是其发生的重要机制,辅助型T细胞17(Th17)/调节性T细胞(Treg)是一对重要的促炎/抗炎免疫调节细胞,二者失衡在ARDS中被证实,但对其发生的机制及认识缺乏统一的解读,因此,本文就Th17/Treg在ARDS中发挥免疫调节作用的最新研究进展进行综述。

Acute respiratory distress syndrome (ARDS) is common disease in the clinic which induce a high mortality of 40%. Unbalanced inflammation plays a key role in pathophysiological mechanisms of ARDS development. T helper 17(Th17) and regulatory T (Treg) cells are a pair of CD4+ T cell subsets with opposite functions. Th17 cells can mediate inflammatory response while Treg cells can inhibit T cell-mediated inflammation and maintain immune tolerance. The imbalance of these two T cell subsets are exist in ARDS, but the mechanism and understanding of Th17/Treg imbalance remains lack of consensus. In this review, we will focus on the recent ?ndings related to role of Th17/Treg imbalance in immunity regulating in ARDS.

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